Molecular and biochemical toxicology / edited by Robert C. Smart and Ernest Hodgson

Contributor(s):

Material type: Text

TextPublisher: Hoboken, NJ : Wiley, 2018Edition: 5th edISBN:

9781119042419
9781119042426
9781119042433

Subject(s):

Biochemical toxicology

DDC classification:

E-BOOK (Available ON-CAMPUS only)

Online resources:

Click here to access online

Contents:

- 1 Molecular and Biochemical Toxicology: Definition and Scope - - 2 Molecular Techniques for the Study of Gene Function - - 3 Transcriptomics - - 4 Proteomics - - 5 Metabolomics - - 6 Cellular Techniques - - 7 Basic Concepts of Molecular Epidemiological Research Methods - - 8 Phase I and Phase II Metabolism and Metabolic Interactions: A Summary - - 9 Structure, Mechanism, and Regulation of Cytochromes P450 - - 10 Polymorphisms in Phase I and Phase II Genes and Outcomes - - 11 Cellular Transport and Elimination - - 12 Nuclear Receptors - - 13 Mechanisms of Cell Death - - 14 Mitochondrial Dysfunction - - 15 Reactive Metabolites, Reactive Oxygen Species (ROS), and Toxicity - - 16 DNA Damage and Mutagenesis - - 17 DNA Repair - - 18 Carcinogenesis - - 19 Molecular Mechanisms of Respiratory Toxicity - - 20 Molecular Mechanisms of Hepatotoxicity - - 21 Molecular Mechanisms of Renal Toxicology - - 22 Molecular Mechanisms of Neurotoxicity - - 23 Molecular Mechanisms of Immunotoxicity - - 24 Molecular Mechanisms of Reproductive Toxicity - - 25 Molecular Mechanisms of Developmental Toxicity - - 26 Computational and Molecular Approaches to Risk Assessment - - 27 Nanotoxicology - - 28 Developmental Origins of Health and Disease - - 29 Exposome

Summary: Written as an advanced text for toxicology students, this book is much more than an introduction and provides in-depth information describing the underlying mechanisms through which toxicants produce their adverse responses.• Links traditional toxicology to modern molecular techniques, important for teaching to graduate courses and professional studies• Uses a didactic approach with basic biological or theoretical background for the methodology presented• Brings together and comprehensively covers a range of dynamic aspects in biochemical and molecular toxicology• Guides student and professional toxicologists in comprehending a broad range of issues, compiled and authored by a diverse group of experts•

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- 1 Molecular and Biochemical Toxicology: Definition and Scope
- - 2 Molecular Techniques for the Study of Gene Function
- - 3 Transcriptomics
- - 4 Proteomics
- - 5 Metabolomics
- - 6 Cellular Techniques
- - 7 Basic Concepts of Molecular Epidemiological Research Methods
- - 8 Phase I and Phase II Metabolism and Metabolic Interactions: A Summary
- - 9 Structure, Mechanism, and Regulation of Cytochromes P450
- - 10 Polymorphisms in Phase I and Phase II Genes and Outcomes
- - 11 Cellular Transport and Elimination
- - 12 Nuclear Receptors
- - 13 Mechanisms of Cell Death
- - 14 Mitochondrial Dysfunction
- - 15 Reactive Metabolites, Reactive Oxygen Species (ROS), and Toxicity
- - 16 DNA Damage and Mutagenesis
- - 17 DNA Repair
- - 18 Carcinogenesis
- - 19 Molecular Mechanisms of Respiratory Toxicity
- - 20 Molecular Mechanisms of Hepatotoxicity
- - 21 Molecular Mechanisms of Renal Toxicology
- - 22 Molecular Mechanisms of Neurotoxicity
- - 23 Molecular Mechanisms of Immunotoxicity
- - 24 Molecular Mechanisms of Reproductive Toxicity
- - 25 Molecular Mechanisms of Developmental Toxicity
- - 26 Computational and Molecular Approaches to Risk Assessment
- - 27 Nanotoxicology
- - 28 Developmental Origins of Health and Disease
- - 29 Exposome

Written as an advanced text for toxicology students, this book is much more than an introduction and provides in-depth information describing the underlying mechanisms through which toxicants produce their adverse responses.• Links traditional toxicology to modern molecular techniques, important for teaching to graduate courses and professional studies• Uses a didactic approach with basic biological or theoretical background for the methodology presented• Brings together and comprehensively covers a range of dynamic aspects in biochemical and molecular toxicology• Guides student and professional toxicologists in comprehending a broad range of issues, compiled and authored by a diverse group of experts•

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